Preimplantation Genetic Testing (PGT)
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About Preimplantation Genetic Testing (PGT)
Preimplantation Genetic Testing (PGT) can test embryos created with in vitro fertilization (IVF) before they are transferred into the uterus for pregnancy. There are different types of PGT: PGT-A, PGT-SR and PGT-M.
Your PGT Journey Begins Here
PGT is an add-on to an IVF cycle and eliminates the possibility of doing a fresh embryo transfer after IVF. Therefore, those using PGT should expect to delay the embryo transfer after an IVF cycle by as much as two months. Results from genetic testing will vary depending on the test. Expect to wait x weeks for several weeks for PGT-A results. PGT-M and PGT-SR can extend the process by several months as the genetics lab needs to develop special probes.
Attend a PGT-A webinar
Join the LIVE PGT-A webinar hosted by one of our Genetic Counsellors. This webinar is free for our patients. Ask your clinical coordinator for details.
Make a decision about PGT ad inform your Clinical Coordinator
If you wish to proceed with PGT-A in your IVF cycle, your clinical coordinator will arrange for you to sign the required consent forms and facilitate the PGT-A testing.
In-depth Discussion with Genetic Counsellor
If you are considering PGT-M or PGT-SR, a consultation with a genetic counsellor is required to provide you with information about the testing and help you decide about proceeding with the testing. With PGT-M and PGT-SR, the genetics team will work closely with the PGT reference lab (CooperGenomics) to confirm that PGT-M or PGT-SR can be used to test your embryos. This must happen before you can start your IVF cycle to make embryos.
For PGT-M, the Test Development with the PGT lab can take up to 3 months to complete and may require samples from other family members.
Development of Genetic Probes for PGT-M and PGT-SR Only (3-4 months)
If you are considering PGT-M or PGT-SR, it typically takes some time 3 to 4 months to develop probes to be used in testing. These are developed based on your specific genetic traits.
PGT-A does not require the development of probes and therefore is a much shorter process.
Complete an IVF Cyce
Genetic testing of embryos occurs only after a completed IVF cycle. Please refer to the process of IVF for more information on what is involved to retrieve and fertilize eggs. Once we have blastocyst embryos, we can begin the process of genetic testing.
Embryos are biopsied at blastocyst stage, usually 5-6 days after fertilization. The embryologist will remove a few cells from the outer part (trophectoderm) of the embryo and ship the biopsied cells to the PGT lab for analysis. The embryos are then frozen on-site and can remain frozen until embryo transfer.
PGT results are reported approximately 2-3 weeks after embryo biopsy. Our Genetic Counsellor will contact you when the results are received and arrange a review of the results. Following a review with the Genetic Counsellor, you will meet with your physician to make a plan for embryo transfer.
The final step in a PGT cycle is to transfer an embryo that has been tested an analyzed for genetic abnormalities.